ピルビン酸カルシウムイソニアゾンの物理化学的研究 (第7報)
イソニアジド誘導体の加水分解反応について
1963 年 83 巻 6 号 p. 594-597
詳細
1963 年 83 巻 6 号 p. 594-597
In order to find the effect of pH on the hydrolytic reaction of INAH derivatives (isoniazones of calcium pyruvate, sodium pyruvate, sodium glucuronate, glucose, and sodium o-phthalaldehydate), hydrolysis rate of these derivatives at 25° and 36° was measured in buffer solutions of pH 2.08 to 7.02. It was found that a relation of k=k0⋅[H3O+] exists between the rate constant k and [H3O+], and the values of k, k0, half-life t1/2, and equilibrium constant K were determined. A close correlation was found to exist between this hydrolytic reaction and pharmaceutical effect.
