Studies on the Chlorophyllin Chelate Compounds as the Chemical Protector against Radiation Injury

Abstract

Either sodium or potassium salt of Mg-, Co-, Mn-, V-, Ag-, Zn-, Au-chlorophyllin and Co-chlorophyllin coordinated with either methionine, adenine, folic acid or ammine ion, which is chelated by phytochlorin derived from chlorophyll, were prepared in order to examine chemical protectors against radiation injury. Animal experiments of each of chlorophyllin metal chelate compounds for LD₅₀ showed very low toxicity. The protective effect of the compound against radiation injury was determined by comparative study on survivals between the treated and untreated mice following to the lethal general irradiation. Consequently, a survival rate of the treated groups were found to be superior to the untreated groups, and the hexacoordinated chlorophyllin metal (Co, Mg, Mn and V) chelate compounds were found to be effective.