抄録
Sodium cyclamate (sodium N-cyclohexanesulfamate) is hydrolyzed in hydrochloric acid, in the presence of hydrogen peroxide, and forms cyclohexylamine. When the concentration of cyclohexylamine in the hydrolysis solution was less than 0.025%, the amine was extracted with chloroform, ethanolic solution of quinhydrone was added to it, and the mixture was warmed at 50° for 2 hours, giving cyclohexylamino-1, 4-benzoquinone (I), m. p. 96-98°. I was also obtained by the use of 1, 4-benzoquinone in place of quinhydrone.
When the concentration of cyclohexylamine was over 0.25%, excess of manganese dioxide was added to the hydrolysis solution to decompose hydrogen peroxide, the solution adjusted to pH 9.0 with a buffer solution, and ethanolic solution of quinhydrone was added. The mixture was warmed at 50° for 15 minutes, and extracted with chloroform in hydrochloric acidity, by which 2, 5-bis(cyclohexylamino)-1, 4-benzoquinone (II), m. p. 242°, was obtained. II was also obtained by refluxing 2, 5-dimethoxy-1, 4-benzoquinone and cyclohexylamine in ethanol. I and II were identified as the colored substances obtained in the quinhydrone method for identification of sodium cyclomate.
