2 (or 2,5-Di)-Substituted-1,3,4-thiadiazole誘導体の合成

抄録

2-Sulfanilylamino-1, 3, 4-thiadiazoles (VII) possessing a heterocycle in the 5-position were synthesized by the condensation of N-acetylsulfanilyl chloride with 2-amino-1, 3, 4-thiadiazole with a heterocyclic substituent in the 5-position. The latter was obtained by heating the corresponding aldehyde thiosemicarbazone with ferric chloride solution. The treatment of the aldehyde 3-thio-4-(N-acetylsulfanilyl) semicarbazone with ferric chloride also afforded VII. Various kinds of 2-dialkylaminoacylamino-1, 3, 4-thiadiazoles were obtained by the application of haloacyl halide to 2-amino-1, 3, 4-thiadiazole, followed by amination. The addition of amines to 2-crotonamido-1, 3, 4-thiadiazole gave the dialkylaminobutyrylamino derivative.