N-メバロノイル-β-アラニンの合成とその生物学的活性に関する研究 (第1報)
N-メバロノイル-β-アラニンエチルエステルの合成
1965 年 85 巻 12 号 p. 1068-1070
詳細
1965 年 85 巻 12 号 p. 1068-1070
The present experiments were undertaken in order to clarify the biological activity of N-dl-mevalonoyl-β-alanine, a new compound and an isomer of pantothenic acid. In the present series of work, condensation of dl-mevalonic lactone (I) and β-alanine ethyl ester (II) was carried out by heating in dehyd. ethanol at 65° for 30 minutes and the objective N-dl-mevalonoyl-β-alanine ethyl ester (III) was obtained as a crude product. This product was purified through column chromatography using Silica Gel Q-23 (Wako) and a purified product (III) was obtained as a colorless, hygroscopic, viscous liquid, in 51% yield calculated from I.
