Abstract
A screening test of blood sugar descending action was carried out with 41 kinds of sulfonylurea, semicarbazide, benzothiadiazine and biguanide derivatives. As to a few effective compounds, the efficacy ratio and the tests towards acute toxicity and chronic toxicity were examined and 1-(p-chlorophenylsulfonyl)-3-pyrrolidinourea (No. 7) was found to be effective. The correlation between concentration in serum and blood sugar value was further investigated.
