Abstract
As one of the applications of mass spectrometry of organic compounds, an analysis of mixed medicines was attempted and various preparations were found to be easily analyzed from the characteristics of each fragment, without the interpretation of the fragmentation.
Comparing with the usual analytical methods, mass spectrometry showed the following benefits: 1) the analysis is capable in a minute amount of 0.1-1mg. scale. 2) it can be operated within a very short period of time of 10-20min. 3) no pretreatment for the seperation is unnecessary, and 4) no indivisual error and a high reproducibility are found by the peaks correspondingto the mass numbers. Besides, 5) no influence is effected by the diluents such as starch in the preparations and by the stabilizers and preservatives in the ampoules. 6) applying the benefit of giving mass spectrum of free base, in spite of the kinds of salts.
Therefore an identification of morphine, codeine, papaverine, thebaine, dihydrocodeine and atropine in the opium alkaloids has been studied. The quantitative treatment of hose components, according to the type analysis of the spectra, is examining.
