1966 年 86 巻 10 号 p. 906-910
Action mechanism of the leukocytosis-promoting activity of Saliva Parotin-A was examined by using intact and X-irradiated rabbits. This activity of Saliva Parotin-A is chiefly carried on by granulocytes, and effects weak decreasing action on lymphocytes and monocytes. The serum from rabbits 2 and 6 hours after the administration of Saliva Parotin-A has a strong leukocytosis-promoting activity originating from granulocytes. Since the immunochemical measurement revealed that this reaction is not due to the originally administered Saliva Parotin-A, it is considered that a leukocytosis-promoting factor is produced secondarily in vivo by the administration of Saliva Parotin-A, and this factor appears in the serum. This factor was observed similarly in both X-irradiated and intact rabbits.