Corpaverine関連化合物の合成研究(第1報) : 1-(p-Hydroxybenzyl)-2-methyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinolineの合成 : 複素環式化合物の合成研究 第139報

抄録

As a part of work on the syntheses of compounds related to corpaverine, one of its isomers, 1-(p-hydroxybenzyl)-2-methyl-6, 7, 8-trimethoxy-1, 2, 3, 4-tetrahydroisoquinoline (XVIII), was synthesized. Condensation of 6, 7, 8-trimethoxyisoquinoline methiodide and p-nitro-toluene, in the presence of sodium hydride, gave 1-(p-nitrobenzyl) compound (XV) which was reduced to the amino compound (XVII), diazotized, and decomposed into XVIII. XVIII was also synthesized from mescaline via XIX, XX, XXI, and XXII by the usual method, and the two kinds of compounds so obtained were identified by mixed fusion and infrared absorption spectra.