Abstract
Some 2-substituted-3, 5, 6-trimethylpyrazine derivatives were synthesized from 2-chlorotrimethylpyrazine and, by their antibacterial tests, 2-mercapto and 2-(p-nitrophenylsulfonyl) derivatives were found to have antibacterial activities against gram-positive bacteria (Staphylococcus aureus). 2-Sulfanilamido derivative exhibited the same minimum inhibitory concentration against gram-negative bacteria (Eschericherichia coli) as against gram-positive bacteria (Staphylococcus aureus).
