Abstract
In order to examine the effect of a substituent on ring fission, benzyl 5-(p-R-phenyl)-2-oxazolecarbamate (I) and 2-amino-5-(p-R-phenyl) oxazole (II) were synthesized, where R was Cl, OH, CH3O, CH3SO2, C6H5, C6H5CH2O, NO2, or NH2. These compounds were submitted to catalytic reduction using palladium-carbon, palladium-barium sulfate, or platinum oxide catalyst. Selectivity of the catalyst and effect of the solvent were approximately the same as those in the case of R=H, as reported in the preceding paper.*1 The substituents present in these compounds were found not to give any marked effect on the ease or difficulty of ring fission.
