Abstract
In the course of studies on thiamine disulfides, new compounds, thiamine dialkyl phosphate disulfides (III) such as diethyl (IIIa), dipropyl (IIIb), dibutyl (IIIc), and diphenyl (IIId), were synthesized by the oxidation of corresponding thiamine dialkyl phosphate (I) in alkaline solution (method A) and by the dialkyl phosphorylation of thiamine disulfide (IV) with dialkyl phosphorochloridate in pyridine (method B). Oxidation reagents used in method A were iodine, potassium ferricyanide, and hydrogen peroxide. The compounds synthesized by the above two methods were proved to be identical by IR spectra and thin-layer chromatography.
