YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on Antifungal Substances. VII. : Studies on the Solubility of Various Dequalinium Salts. (1). Solubility of Dequalinium Salicylate, Chloride in Water-Propylene Glycol-Ethanol Systems
Toshio AnmoMitsunori WashitakeHiroyuki ShinkaiTomokazu Suzuki
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1967 Volume 87 Issue 1 Pages 74-82

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Abstract
The solubility of dequalinium salicylate (I) and dequalinium chloride (II) in water, ethanol, propylene glycol, and combination of these solvents was determined at 0°, 20°, 40°, and 60° by analytical method using ultraviolet absorption. Its results showed that I and II were more easily dissolved in mixed solvents than in individual solvent, and exhibited pronounced maximum solubility in each solvent system. Further, the solubility curves drawn on the triangle diagram indicated that the component of maximum solubility of I and II in mixtures of water, ethanol, and propylene glycol were respectively in a ratio of 25 : 35 : 40, and 15 : 15 : 70.
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