Thiohydantoin関連化合物の合成ならびに抗菌性の研究(第12報) : 5-Benzylidene-2-thiohydantoin類のアルキル化合物および2-Substituted-5-benzylidenehydantoin化合物の合成
1967 年 87 巻 2 号 p. 142-147
詳細
1967 年 87 巻 2 号 p. 142-147
Starting with 5-(p-chlorobenzylidene)-2-thiohydantoin and 5-(p-methoxybenzylidene)-2-thiohydantoin, their monoalkyl (II to IX or II' to IX') and dialkyl compounds (X to XVII) (R=CH3, C2H5, n-C3H7, n-C4H9) were prepared. Heating of these compounds with conc. hydrochloric acid afforded 3-alkyl-5-benzylidenehydantoins (XVIII to XXVII), and reaction with acetic anhydride have acetylated compounds (XXVIII to XXXI). Reaction with hydrazine hydrate afforded hydrazino compounds (XXXIV to XXXVII). Reaction with phenylhydrazine and some amines was also carried out and 2-substituted compounds (XL to XLIII) were prepared. Growth-inhibiting action of these compounds against tubercle bacclli was examined.
