Quantitative Analysis of Active Components in Ointments by X-Ray Diffractometry. I. : Analysis of Boric Acid and Zinc Oxide in Ointments.

Abstract

In order to utilize the X-ray diffraction method for the determination of crystalline component in ointments, determination of boric acid and zinc oxide was carried out on various ointments having white petrolatum as the ointment base, since approximation of its mass absorption coefficient can be calculated, and containing boric acid and zinc oxide as the chief components since these are used frequently. The method of determination used both the direct and internal standard (magnesium oxide) methods. It was thereby found that this method is quite practicable. The largest factor that caused the greatest scattering of the values in diffraction intensity was found to be the method of fixing the sample to the holder. Determination error by this method is greater than that by the method stipulated by the Japanese Pharmacopoeia, but the method is advantageous in several respects such as no necessity for extraction, comparatively short period of the whole procedure, and small amount of sample necessary.