Quantitative Analysis of Active Components in Ointments by X-Ray Diffractometry. III. : Analysis of Salicylic Acid, Ethyl Aminobenzoate and Sulfisomidin in Ointments.

Abstract

Determination of the chief components in an ointment was carried out on various ointments having white petrolatum as the base and containing salicylic acid, ethyl aminobenzoate, and/or sulfisomidine, employing the X-ray diffraction by the direct method and by the internal standard method using magnesium oxide as the standard. The mass absorption coefficient, μ, of these main components is approximately the same as that of the base, and the concentration of the chief component and intensity of the diffraction lines in the direct method were approximately linear. Determination of these ointments by the X-ray diffraction method seems to be practicable.