皮膚真菌症の実験化学療法的研究(第5報) : Arylhaloacetamide系化合物の真菌に対する抗〓作用について
1968 年 88 巻 12 号 p. 1602-1609
詳細
1968 年 88 巻 12 号 p. 1602-1609
The 55 derivatives of arylhaloacetamide, which were synthesized, were tested for their fungicidal and bactericidal properties against Trichophyton asteroides and other fungal or bacterial pathogens in vitro. Outstanding among them was N-(α-naphthyl)iodoacetamide (NIA), which was found to combine a strong fungicidal action with less skin irritation and toxity to mammals compared to pentachlorophenol (PCP) as a control substance. The results of therapeutic test in guinea pigs revealed that a hydrophilic ointment containing 1-2% NIA had about 50% cure rate on experimental candidiasis and dermatomycosis, and that containing PCP or salicylic acid besides NIA, about 60%.
