Abstract
It is necessary, in order to diminish the differences in weight distribution of tablets, to control compression punch and die to make its size uniform. It is also important to have the material of good fluidity, with sufficiently small size in comparison with the compression punch size, and having uniform granularity, to adopt filling mechanisms suited to the physical properties of the material to be compressed, and to compress with strong, highefficiency tableting machine of good precision, It is natural, though not experimentally proved, that care should be taken to correlate the compressing mechanism with compounding formula so as not to cause friction, sticking, chipping, and capping which are the greatest cause in producing weight variation of tablets. After setting up the procedure with above precautions, it is still necessary to control the actual work by seeing that the hopper is always filled to more than one-half of its capacity with the material to be compressed, with the effective use of control limit from the x^- chart, or by automatic control with automatic weight control device. The tablets produced immediately after start of the work and those immediately before the end of the work should be removed, or inspected carefully. It is important to know the limit of tableting speed from the relationship between the physical properties of the material to be compressed and capacity of the tableting machine, and to make tableting speed as fast as possible.
