Influence of Inflammation on the Phospholipid Metabolism in Skeletal Muscle of Mouse and Action of Anti-Inflammatory Steroid

Abstract

Influence of inflammation on the phospholipid metabolism in skeletal muscle and action of anti-inflammatory drugs on that were examined. Phospholipid content in skeletal muscle increased by inflammation and reached a maxium on the sixth day of inflammation. Incorporation of orthophosphate-³²P into phospholipid of skeletal muscle was also increased by inflammation and reached a maxium on the fourth day of inflammation. The increase of incorporation of orthophosphate-³²P into phospholipid by inflammation was inhibited by subcutaneous injection of cortisone or prednisolone. The incorporation of orthophosphate-³²P into phospholipid in inflammatory skeletal muscle was inhibited by the addition in vitro of cortisone, prednisolone, or dexamethazone but that of intact muscle was not affected.