炎症によるマウス骨格筋内のリン脂質代謝の変化とそれに対するステロイド性抗炎症剤の作用について

抄録

Influence of inflammation on the phospholipid metabolism in skeletal muscle and action of anti-inflammatory drugs on that were examined. Phospholipid content in skeletal muscle increased by inflammation and reached a maxium on the sixth day of inflammation. Incorporation of orthophosphate-³²P into phospholipid of skeletal muscle was also increased by inflammation and reached a maxium on the fourth day of inflammation. The increase of incorporation of orthophosphate-³²P into phospholipid by inflammation was inhibited by subcutaneous injection of cortisone or prednisolone. The incorporation of orthophosphate-³²P into phospholipid in inflammatory skeletal muscle was inhibited by the addition in vitro of cortisone, prednisolone, or dexamethazone but that of intact muscle was not affected.