Influence of Taurine Analogue on the Absorption of Salicylic Acid Derivatives in Rat Gastrointestinal Tract

Abstract

It was clarified through animal experiments with rats that absorption of salicylic acid series compounds, such as aspirin, through the digestive tract was accelerated by the presence of an additive of taurine-like or related compounds such as glycine, glycine ethyl ester, sarcosine, and l-, d-, and β-typg alanines. Distribution coefficient of aspirin and such compounds was found to remain unchanged by the presence of these additives, and it was assumed that the action of these additives was specific to the membraneous surface of the digestive tract. Such effect of the additives was also indicated in the measurement of urinary excretion of salicylic acid series compounds after their oral administration in rats, and approximate correlation between was confirmed.