薬剤の安定性に関する研究(第19報) : ベンゾサイアダイアジン系化合物の安定性 その10 : 混合溶媒中におけるクロロサイアザイドの加水分解反応について

抄録

The influences of the solvents on the rate constants were investigated for the degradation of chlorothiazide (I) in phosphate buffer solutions (pH 7.9, μ=0.1) at 87.5°. The specific rate constants decrease with increasing concentrations of organic solvents (ethanol, n-propanol, propylene glycol, acetone, dioxane) down to 10-20%. A slight increase of the specific rate constants occurs at higher solvents concentration. The results are not in agreement with the Laidler's electrostatic theory.