ピロリジン系薬理作用物質の合成研究(第6報) : 1,2-Dimethyl-3-[bis(2-thienyl)-methylene]pyrrolidineおよび1-[1,1-Bis(2-thienyl)-3-propenyl]-2-methylpyrrolidineの合成

抄録

In order to examine pharmacological activities, 1, 2-dimethyl-3-[bis(2-thienyl) methylene] pyrrolidine (I) and 1-[1, 1-bis(2-thienyl)-3-propemyl]-2-methylpyrrolidine were synthesized. I and II are prepared by Grignard reaction between either ethyl 1, 2-dimethyl-3-pyrrolidinecarboxylate (IV) or ethyl 2-methyl-1-pyrrolidinepropionate (XI) and 2-thienylmagnesium bromide, followed by the dehydration. A special examination was made on the novel synthesis of IV from the starting material ethyl 2-cyanomethylacetoacetate.