抄録
Crude saikosides are crude saponin fraction extracted from Bupleurum falcatum L. some pharmacological properties, particularly the acute toxicity ana the central depressant action of this fraction were described. Crude saikosides showed a strong toxic effect by intraperitoneal administration but low toxicity by oral route. High hemolytic value was obtained with this crude saponin. Crude saikosides had potent sedative, analgesic, hypothermic and antipyretic effect. Furthermore they had a potent antitussive effect. On the other hand they did not show any anticonvulsant activity nor reduction of muscle tone using the grip strength test. From these findings it may be concluded that crude saikosides have a strong central depressant action.
