狭心症治療薬の家兎による心電図的評価試験法

抄録

Effect of medicinals on electrocardiographic tests was examined using pentobarbital-anesthetized normal and arteriosclerotic rabbits in order to develope a therapeutic agent for angina pectoris. Examinations were made on the acute effect of various medicinals as follows : (1) Hypoxemia test : ST depression at the time of low-oxygen laoding in arteriosclerotic rabbit; (2) Isoproterenol test : ST depression at the time of isoproterenol loading in mormal and arteriosclerotic rabbits; (3) Vasopressin test : ST and T elevation at the time of vasopressin loading in mormal rabbits; (4) coronary arterial ligation method : ST elevation by chronic coronary arterial ligation in normal rabbits; (5) RPQ index test : Measurement of RPQ index, which is an indirect index of oxygen consumption by myocardium, with each medicinal. The medicinals which showed some effect were adenosine, 4, 4'-(diethylaminoethoxy)hexoestrol, pronethalol, and iproveratril, in (1), 4, 4'-(diethylaminoethoxy)hexoestrol, propranolol, pronethalol, and iproveratril in (2), dipyridamol in (3), ATP, adenosine, 4, 4'-(diethylaminoethoxy)hexoestrol, and propranolol in (4), and ATP, dipyridamol, propranolol, 4, 4'-(diethylaminoethoxy)-hexoestrol, and nitroglycerin in (5).