Abstract
A peptide-like substance was isolated from pseudoglobulin fraction of the exudative inflammatory skin by carboxymethylcellulose. This substance showed an accelerating effect on the permeability of the venule wall, while it had no influence on the leucocyte migration. Further, contraction of the rat uterus was not induced by this permeability substance in vitro, unlike bradykinin. The interrelation between some anti-inflammatory drugs and the permeability substance was also examined by dye leakage method using pontamine sky blue in rat skin.
