抄録
2-Amino-3-ethoxycarbonyl-6-benzyl-4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridine (Y-3642) and its hydrochloride (Y-3642 HCl) showed the same potent analgesic activity as aminopyrine in both benzoquinone writhing test in mice and tail pressure test in rats, but in electric stimulation test, activity of Y-3642 HCl was one-half of that of aminopyrine. The mode of action of Y-3642 and its hydrochloride seemed to be similar to that of aminopyrine. These compounds inhibited non-specifically several experimental edemas induced by dextran, formalin, serotonin, and bradykinin. The anti-edematous action of Y-3642 and its hydrochloride is similar to that of acetylsalicylic aicd, but more active.
