抗炎症薬に関する研究(第4報) : 2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(Y-3642)の反復投与による身体依存性および鎮痛作用の検討

抄録

Appearance of physical dependence of 2-Amino-3-ethoxycarbonyl-6-benzyl-4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridine (Y-3642) was tested on rats, comparing with that of morphine as a control. Y-3642 was given orally and morphine was given subcutaneously to test animals. Decrease in body weight due to physical dependence was observed, if the administration was discontinued or otherwise when either levallorphan or Y-3642 was administered instead of morphine after a repeated administration of morphine (100mg/kg/day) to rats twice a day. No decrease in body weight was observed in rats treated previously with repeated administration of Y-3642 (100mg/kg/day, twice a day), when the administration was stopped or levallorphan was given instead of Y-3642. In the rat tail pressure method, the analgesic activity of Y-3642 was not changed during repeated administration of Y-3642 (50 or 100 mg/kg/day, i.p. once a day). But that fo morphine (2.5 or 10mg/kg/day, i.p. once a day) was markedly decreased. These results suggest that analgesic action of Y-3642 is similar to non-narcotic analgesic such as aminopyrine, and the compound is not a narcotic substance.