向精神薬に関する研究(第5報) : 8-[3-(2-Chloro-10-phenothiazinyl)propyl]-1-thia-4,8-diazaspiro[4,5]decan-3-one Hydrochloride(APY-606)の薬里作用

抄録

A new derivative of phenothiazine, 8-[3-(2-chloro-10-phenothiazinyl) propyl]-1-thia-4, 8-diazaspiro [4, 5] decane-3-one hydrochloride (APY-606), was examined for its pharmacological activities in comparison with chloropromazine and thioridazine as the standard compounds. APY-606 has a potent sympatholytic action with a low toxicity, although it is a phenothiazine derivative. APY-606 has a characteristic spectrum of pharmacological activities, which differs from those of standard compounds. This compound may prove to be a new type agent having a psychotropic activity in clinical use.