ベルベリン型アルカロイド誘導体の研究(第5報) : Tetrahydroberberineメチン塩基塩酸塩の熱分解について
1970 年 90 巻 8 号 p. 1012-1015
詳細
1970 年 90 巻 8 号 p. 1012-1015
In order to carry out the conversion of protoberberine-type alkaloids to benzo[c]phenanthridine-type alkaloids by a synthetic means, thermal decomposition of the hydrochloride of tetrahydroberberine methine base (I) was carried out and hitherto unknown bases were obtained; base A of rap 168° and base B of mp 156°. By decomposition reaction, these two bases were identified as stereoisomers of 1, 2-(3, 4-methylenedioxyphenyl)-3-methyl-6, 7-(2, 3-dimethoxyphenyl)indolizidine (III). From the results of infrared and nuclear magnetic resonance (NMR) spectra, steric structures III A and III B were respectively assigned to bases A and B.
