Abstract
Inhibitory effect of aminoethylisothiuronium (AET) and its derivatives on dopamine-β-hydroxylase was examined. Among the tested compounds, 2-aminoethyl-N-α-naphthyl-isothiuronium bromide hydrobromide (AENT) was the most active inhibitor. Inhibition by AENT was not competitive with substrate and was not affected by cosubstrate, i.e., bycorbic acid or fumaric acid, but was reversed as addition of Cu2+. Structure-activity-relationship between the AET derivatives and the inhibitory effect on dopamine-β-hydroxylase was discussed.
