Studies on Tertiary Amine Oxides. XLI. : Preparation of Aromatic N-Oxides of Pyridine Series by Oxidation with Hydrogen Peroxide-Sodium Tungstate

Abstract

Treatment of heteroaromatics of pyridine series with hydrogen peroxide-sodium tungstate in the presence of EDTA at 60-65° gave the corresponding amine oxides in generally good yields. The reactions in the absence of EDTA gave somewhat inferior results. 2-Aminoquinoline was oxidized to 2-aminoquinoline 1-oxide and 2-nitroquinoline. This procedure is rather simple and worth trying for preparation of aromatic amine oxides in some cases.