イミダゾリジノン系化合物の薬剤学的研究(第5報) : 1,2-Dimethyl-3-phenyl-4-imidazolidinoneおよび3-Phenyl-4-imidazolidinoneの血中における安定性

抄録

The stability of 1, 2-dimethyl-3-phenyl-4-imidazolidinone (IMO-1) with a fast decomposition rate and 3-phenyl-4-imidazolidinone (IMO-4) with a low rate in rat blood was investigated. Both α-methylaminoacetanilide (IMO-D) and glycylaniline, which are decomposition products of IMO-1 and IMO-4, respectively, were metabolized to aniline in blood. It was found that the decomposition rate of glycylaniline was much larger than that of IMO-D. On the other hand, acetaldehyde produced from IMO-1 disappeared rapidly from blood by the attack of enzymes and protein binding. This result strongly suggested that IMO-1 was scarcely affected by the contribution of a reversible reaction, and appeared to be rapidly broken down by the first-order reaction in blood. These facts reveal that IMO-1 easily produced aniline, in contrast to IMO-4 which was quite stable and does not form aniline in blood.