Trichothecium roseum LINKの代謝産物の研究Rosein IIIの構造

抄録

Rosein III, C₂₀H₂₈O₄, mp 226°, a metabolite of Trichothecium roseum LINK, was converted to ros-5, 10-en-16-oic acid (9), and also more directly to a mixture of dihydrorosenono-(16) and dihydroisorosenono-lactone (17) via a novel cyclopropane intermediate (12). These correlations of rosein III with rosenonolactone (1) in association with the spectroscopic evidences of derivatives substantiated its structure and absolute configuration as 11-β-hydroxyrosenonolactone (2). The conformation of isorosein III, a C-8-isomer of rosein III, was also clarified as (14c) in which ring B has 7, 10-RT-twist conformation.