Abstract
In order to examine the anti-inflammatory and analgesic activities of indoline derivatives, 3-substituted 1-benzylindolin-2-ones were synthesized. Anti-inflammatory and analgesic actions of 21 of these derivatives were examined by the antiwrithing test in mice and, at the same time, their effect on general behavior and their acute toxicity were also tested. Compounds with strong antiwrithing activity and low toxicity were found in 3-substituted aminomethyl-3-hydroxy compounds.
