Heterocyclic 環を有する Amidine 系化合い物の薬理作用(第4報) : 1-Phenyl-4-guanylpiperazine Sulfate(PGP)のシロネズミ脳および心臓の Norepinephrine 含量におよぼす影響
1971 年 91 巻 12 号 p. 1381-1383
詳細
1971 年 91 巻 12 号 p. 1381-1383
The actions of 1-phenyl-4-guanylpiperazine sulfate (PGP), which has the property of monoamine oxidase inhibitor and of Nialamide on the concentration of norepinephrine (NE) in the brain and heart of rats were investigated. PGP increased the NE concentration by about 34.5% in the brain and 42.7% in the heart, and Nialamide also increased it by about 33.7% in the brain and 76.3% in the heart 24 hours after the intraperitoneal administration of 100 mg/kg. These percentage were significant (p<0.05).
