Starting with 4-chloro-1-methyl-5-nitroimidazole (V), 4-substituted (alkoxy, aryloxy, alkylthio, alkylamino, arylamino)-1-methyl-5-nitroimidazole (VI), 5-substituted (alkyl or aryl)-3-(1-methyl-5-nitroimidazole-5-yl)-1, 2, 4-oxadiazole (XII), and 5-substituted (alkyl or aryl)-2-(1-methyl-4-nitroimidazole-5-yl)-1, 3, 4-oxadiazole (XVI) were synthesized (Table I-V). Antimicrobial activity of their derivatives in vitro was examined and the results are listed in Table VI.
