1971 年 91 巻 5 号 p. 590-593
Analgesic 5-aminomethylsalicylic acid (V) was obtained by amination (Delepine reaction) of methyl 5-chloromethylsalicylate, prepared by chloromethylation (Blanc-Quelet reaction) of methyl salicylate by treating with formaldehyde and hydrogen chloride in the presence of zinc chloride. Total yield of V was 45% based on methyl salicylate. Similarly, chloromethylation of salicylic acid followed by amination gave V in 40% yield.