人唾液蛋白質の生化学的研究(第8報)緩和な条件下での人唾液からのパロチン様物質の分離
1972 年 92 巻 7 号 p. 796-800
詳細
1972 年 92 巻 7 号 p. 796-800
A parotin-like substance, fraction 100-1, was separatedin a highly purified form from mixed human saliva by mild procedures which comprised acetone fractionation, chromatography on ECTEOLA- and CM-cellulose, and Sephadex G-100 gel filtration. This substance produced hypocalcemia and leucocytosis preceded by transient leucopenia in rabbits with a single intravenous injection of 0.1 mg/kg. It also elicited depression of the serum acid phosphatase activity in a dose of 0.15 mg/kg. It has a molecular weight of 350000 and contains 21.6% galactose and 19.6% glucosamine. The relation of this substance to other patotin-like substances from human saliva is discussed.
