抗動脈硬化剤に関する研究(第7報⁽¹⁾)コンドロイチンポリ硫酸ナトリウムの血中脂質, 凝固線溶系および実験的肝障害に対する作用

抄録

Biological activities were examined on sodium chondroitin polysulfate of low molecular weight, which was obtained from natural chondroitin sulfate-C. Some of them demon-strated lipemia-clearing and anticoagulative activities which were examined in hyperlipemic mice and intact rats, respectively. Sodium chondroitin polysulfate (molecular weight, 4000-6000 ; sulfur content, 13-16%) (CPS) has been selected as having the lowest molecular size with high biological activity. Following results were obtained from pharmacological examinations in view of the antiatherosclerotic activity. 1) Oral Treatment : Hypotriglyceridemia associated with activation of lipopretein lipase was observed acutely in intact and hyperlipemic rats. After a 6-month succesive administation, hypotriglyceridemia was recognized, while normal blood coagulation was observed in intact rats treated with CPS. 2) Intraperitoneal Treatment : Fibrinolytic activity, determined by the time of lysis of euglobulin, is elevated in rats treated with CPS. Further, lipotropic activity of CPS was observed from the experiments on CCl₄-induced injury of rat liver. From these results, characteristic feature of CPS was also discussed with respect to the antiatherosclerotic properties.