Spiro [3-hydroxycyclopentane-1,4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline]の合成
1973 年 93 巻 10 号 p. 1371-1377
詳細
1973 年 93 巻 10 号 p. 1371-1377
For the purpose of testing their biological activity, hydroxy group epimers of spiro-[3-hydroxycyclopentane-1, 4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline](IV and V) were synthesized by cyclization of 1-(m-methoxyphenyl)-3-hydroxycyclopentane-methylamines (XXIIIa and XXIIIb), which were obtained from the corresopnding carboxamide derivatives, in the presence of excess formic acid in the Eschweiler-Clarke reaction.
