Studies on Indole Derivatives. XIX. New Synthetic Methods of 3-Cyanoindole Derivatives from Methyl 3-Indoledithiocarboxylate Derivatives

Abstract

3-Cyanoindoles were synthesized in a good yield by the reaction of methyl 3-indole-dithiocarboxylates and conc. ammonia water. This is a new synthetic method for 3-cyanoindole derivatives. The reaction of 2-hydroxy-3-indoledithiocarboxylates and hydroxylamine also afforded the corresponding 3-cyanoindoles.