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Volume 93, Issue 11
Displaying 1-29 of 29 articles from this issue
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KATSUHIDE MATOBA, NORIKO MIYABAYASHI, TAKAO YAMAZAKI1973 Volume 93 Issue 11 Pages 1401-1405
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSWith excess lithium aluminum hydride, 2-methyl-3-methoxy-2-cyclopentenone (III), 2-ethyl-3-methoxy-2-cyclopentenone (IV), and 2, 5-dimethyl-3-methoxy-2-cyclopentenone (VI) were reduced to the corresponding allyl alcohols, 2-methyl-2-cyclopentenol (Xa), 2-ethyl-2-cyclopentenol (XIa), and 2, 5-dimethyl-2-cyclopentenol (XIIa), respectively. On the other hand, 2, 4-dimethyl-3-methoxy-2-cyclopentenone (V) was reduced to 2, 4-dimethyl-2-cyclopentenol (XIVa), 2, 5-dimethyl-2-cyclopentenone (XIII(v)e), and 2, 4-dimethyl-3-methoxy-2-cyclopenteno1-(XVc). Mechanism if this reduction and the substituent effect are described.View full abstractDownload PDF (622K) -
KATSUHIDE MATOBA, TAKAO YAMAZAKI1973 Volume 93 Issue 11 Pages 1406-1414
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESS2-Methyl-3-methoxy-4-t-butyl-2-cyc1opentenone (VI) and 3-methoxy-4-t-butyl-2-cyclohexenone (IX) were reduced to the corresponding β-methoxy-allyl alcohols with excess lithium aluminum hydride. Under the same conditions, 2-methyl-3-methoxy-5-t-butyl-2-cyclopentenone (VII) was reduced to saturated ketones, allyl alcohols, and diols. On the other hand, from 3-methoxy-6-t-butyl-2-cyclohexenone (X), β-methoxyallyl alcohols, saturated ketones, allyl alcohols, and diols were obtained. The substituent effect of t-butyl group in five-membered and six-membered vinylogous esters was discussed, and a mechanism for the formation of diols was proposed.View full abstractDownload PDF (939K) -
SATOSHI SUGIYAMA, SHIGEO SATO, KAZUTAKA YAMAGUCHI1973 Volume 93 Issue 11 Pages 1415-1417
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSp-Toluidine derivatives of saturated fatty acids were found to be suitable as an internal standard substance for gas-liquid chromatography available in a wide range. Benzarone was assayed within 1% of standard deviation by the use of one of them, under the conditions of 5.9% SE-30 on Chromosorb W at 250°.View full abstractDownload PDF (346K) -
SATOSHI SUGIYAMA, NOBUYUKI SASAKI, KYOKO NAGATSUMA, SHIGEO SATO, KAZUT ...1973 Volume 93 Issue 11 Pages 1418-1421
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSIt was found that alkaline hydrolysis of benzbromarone (II) proceeded by two kinds of cleavage, α and β. The former gave 3, 5-dibromo-4-hydroxybenzoic acid (VI) and 2-ethylbenzofuran (VIII), and the latter gave 3', 5'-dibromo-4'-hydroxy-2-(2-hydroxyphenyl) acetophenone (IV) and propionic acid (IX). IV was completely cyclized to 2-(3, 5-dibromo-4-hydroxyphenyl) benzofuran (V) by heating in the presence of an acid. Determination of the ratio of α and β cleavages was performed by gas chromatography and the predominance of β cleavage was recognized.View full abstractDownload PDF (469K) -
YASUKATSU YUDA, HIROSHI MORIYA, CHIAKI MORIWAKI1973 Volume 93 Issue 11 Pages 1422-1426
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe role of kinins and their related substances in inflammatory process was studied by employing carboxymethylcellulose (CMC) pouch method in a rat. Kinin and kininase activities, pH value, and leucocyte migration in the effusion from experimental CMC pouch were measured, and kininase and kininogen levels in plasma were also determined. An increase of kinins in the effusion was found from 3 to 4 hr after CMC administration, and the content in the 3 hr effusion was higher than that at 4 hr, while an increase of leucocyte migration became significant at 4 hr. From these results, it seems plausible that the kinins found in effusion were not derived from migrated leucocytes but from plasma, because plasma kininogen decrease was found in inflammatory rat. Potent kininases were still found in the effusion in this investigation, and the activity in the effusion elevated parallel with kinin activity in it. Though it has been reported that pH value of inflammatory effusion was acidic and kininases were inactivated in acidic condition, the effusion from CMC-induced inflammation was found to be neutral. It has been widely accepted that kinins might be one of the chemical mediators in inflammatory processes, but the present results seem to indicate that the kinin system may participate only in the very early stage of the processes.View full abstractDownload PDF (642K) -
KEIICHI WATANABE1973 Volume 93 Issue 11 Pages 1427-1432
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThis kinetic study dealt with the hydrolysis of acetylsalicylic acid (ASP) in the aqueous solution of dimethyl sulfoxide (DMSO) at different solvent concentrations, pH, and temperature. The hydrolysis rate at pH 7 and 8 increased with increasing DMSO concentration, but that at pH6 especially decreased at higher concentration than 8 molal DMSO. The reaction rate in aqueous solution at the most stable pH, that is 2.3, also decreased by the addition of DMSO. The pH independent region of the hydrolysis rate observed in aqueous solution from pH 5 to 7 shifted to a higher pH from 9 to 13 by the addition of DMSO. Since the ionic dissociation of ASP observed by ultraviolet absorption was strongly suppressed by DMSO, the decrease of the rate in the aqueous DMSO solution at pH 6 could be mainly due to the decrease of the ASP anion which is a more reactive species. The first-order rate constant of ASP anion estimated by the observed pKa was almost constant below the molar ratio of [DMSO]/[H2O]=0.3, but it increased at a higher concentration of DMSO. The relationship between the reaction rate constant and macroscopic dielectric constant of the solution could not be expressed by Awis' expression of anion-dipole reaction. The relationship between the activation enthalpy and entropy in various aqueous solution, i.e., EtOH, propylene glycol, dimethylacetamide, and DMSO was expressed by a straight line of Leffler's isokinetic equation.View full abstractDownload PDF (621K) -
YOSHINORI TOMINAGA, REIKO NATSUKI, YOSHIRO MATSUDA, GORO KOBAYASHI1973 Volume 93 Issue 11 Pages 1433-1436
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESS3-Cyanoindoles were synthesized in a good yield by the reaction of methyl 3-indole-dithiocarboxylates and conc. ammonia water. This is a new synthetic method for 3-cyanoindole derivatives. The reaction of 2-hydroxy-3-indoledithiocarboxylates and hydroxylamine also afforded the corresponding 3-cyanoindoles.View full abstractDownload PDF (474K) -
TETSUZO KATO, HIROSHI YAMANAKA, HIROSHI FUKUMI, MASAKI NODA1973 Volume 93 Issue 11 Pages 1437-1444
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESS3-Aminocrotonamide (II) reacted with α, β-unsaturated esters (III) in the presence of EtONa to give the corresponding 4-pyrimidone derivatives (VIIa-c) and glutarimide derivatives (VIIIa-c), whereas the use of tert-BuOK resulted in the formation of VIIIa-c and Xc-d. The mechanism of the formation of VII, VIII, and X is described.View full abstractDownload PDF (729K) -
TAKAHIRO FUTAMI, JUNKO NAKAMURA, SHIZUO HAYASHI1973 Volume 93 Issue 11 Pages 1445-1451
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe effect of alkyldimethylbenzylammonium chloride (Alkyl-DBAC) on capillary permeability and on the activity of succinic dehydrogenase was studied in order to understand the inflammatory action of this drug. The capillary permeability increased from 45 min to 4.5 hr after C12-DBAC was intracutaneously injected. The thresholds of capillary permeability fly was 0.01% When C12-DBAC was intracutaneously injected in rabbit, 0.005% when intraperitoneally injected in mice, and 1.0% when externally applied on rabbit. The capillary permeability was influenced by the presence of keratinous layer. The capillary permeability depended on the chain length of Alkyl-DBAC and its maximum was at C12. The activity of succinic dehydrogenase was inhibited by the high concentration of Alkyl-DBAC. The inhibitory action of Alkyl-DBAC reached a maximum at C12. The threshold of C12-DBAC on capillary permeability and the inhibitory concentration on the succinic dehydrogenase were nearly the same but the activity of liver homogenate succinic dehydrogenase was activated by the low concentration of C12-DBAC ana this effect was inhibited by phospholipase C.View full abstractDownload PDF (745K) -
MASANORI YOSHIDA1973 Volume 93 Issue 11 Pages 1452-1456
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe solubilizing action of N-substituted nicotinamides was studied in relation to the adsorption of nicotinamides by carbon black from aqueous solution, and to the partition coefficients in CHCl3-H2O and octanol-H2O systems. The adsorption by carbon black was reversible and isotherms were well expressed by the Langmuir eqution. Amount of N-substituted nicotinamides adsorbed by carbon black increased with the chain length of the substituents in N-substituted nicotinamides. Formation constants of solubilizatenicotinamide complexes had a good correlation with the adsorbability of N-subetituted nicotinamides, except N, N-dialkyl substituents, by carbon black and with the partition coefficients in CHCl3-H2O and octanol-H2O systems.View full abstractDownload PDF (534K) -
TAKEO UEDA, ATSUSHI TAKADA, HITOSHI NISHIKAWA1973 Volume 93 Issue 11 Pages 1457-1462
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSNitrated products of Vitali-Freeman color reaction were investigated. It was concluded from the analytical results of the nitrated products of benzene derivatives in Vitali-Freeman condition that they can be clasified into two groups ; one was colored by their mononitrated product with tetraethylammonium hydroxide (TEAH), and the other, by their polynitrated product. In the nitration of atropine and hyoscyamine, seven compounds were separated by the chromatographic method, and their structures were investigated.View full abstractDownload PDF (619K) -
JUTARO OKADA, KOICHI NAKANO, MICHIHIRO TSUCHIYA1973 Volume 93 Issue 11 Pages 1463-1467
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSBy gas phase reaction of trimethylenediamine and formaldehyde on alumina catalyst, 1-methyl-hexahydro-pyrimidine (I) and 1, 3-dimethyl-hexahydropyrimidine (II) were obtained in a good yield. In a molar ratio of ECHO to trimethylenediamine (TMDA) of 1.34, I was obtained selectively and in the highest yield when reacted at 220°. At the temperature higher than 350°, 2-methylpyridine was obtained. In molar ratio of 2.68, I was obtained more than II in the temperature range of 180° to 240°, but II was obtained more than I in the range of 250° to 290°. At 230°, only I was obtained from a molar ratio of 1.8, and only II in a molar ratio of 4.0. The yield of I and II increased with W/F, and the yield of I was maximum W/F : of 180, but that of II was maximum at W/F : of 220.View full abstractDownload PDF (535K) -
JUTARO OKADA, KOICHI NAKANO, KOJI HAYAKAWA1973 Volume 93 Issue 11 Pages 1468-1473
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe reactions of ethylenediamine (ED) and formaldehyde (FA) in the alumina-packed bed reactor were studied. Methylpyrazine was obtained as the main product, and a small amount of dimethylpyrazine was also obtained. This reaction mechanism is yet unknown, and a statistical method was employed for the determination of optimum condition. The first part of the investigation consisted of 24 factorial design. Four variables were chosen-reaction temperature (A), catalyst weight (B), molar ratio of reactants (C), and the amount of water added (D). In the analysis of variance, all factors except (B) were significant at the 5% level. The interaction between (A) and (C) was checked in a wider range. Through experiments in the direction of the steepest ascent based on the first-order response function, it was found that the yield of methylpyrazine dropped suddenly beyond 410° and it was concluded that the optimum condition are follows : temprature 410°, catalyst weight, 21.92 g, molar ratio FA/ED=2.78, and dilution water 30.49 times mole, which gave the maximum yield of 42.5%.View full abstractDownload PDF (561K) -
TAKEO UEDA, ATSUSHI TAKADA, KUNISHIGE KOSUGI1973 Volume 93 Issue 11 Pages 1474-1480
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESS1, 2-Naphthoquinone-2-acylhydrazones and their derivatives having a sulfonic acid group in 4-position were synthesized, and coloration of these compounds with various metal ions was examined. It was found that 1, 2-naphthoquinone-2-(p-nitrobenzoyl)-hydrazone was useful reagent for the detection of Hg2+, and bis (1, 2-naphthoquinone-4-sulfonic acid)-2, 2-malonyldihydrazone was useful reagent for the detection and determination of Al3+.View full abstractDownload PDF (646K) -
TAKAJI KOYAMA, TAKASHI HIROTA, MASATOSHI YAMATO, SHINYA KOHKI1973 Volume 93 Issue 11 Pages 1481-1483
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSα-Acyl-α-naphthylacetonitriles were heated with HCONH2 and POCl3, and the following results were obtained. 1) In the case of α-acyl-α-(1-naphthyl) acetonitriles, formyl derivative (IIa) gave 4-amino-5-(1-naphthyl) pyrimidine (IIIa), acetyl derivative (IIb) gave 4-amino-6-methy1-5-(1-naphthyl) pyrimidine (IIIb), and benzoyl derivative (IIc) gave IIIa and benzamide (IV). 2) In the case of α-acyl-α-(2-naphtyl) acetonitrilei, formyl derivative (VIa) gave 4-amino-5-(2-naphthyl) pyrimidine(VII), acetyl derivative (VIb) gave 6-methyl-5-(2-naphthyl)-4-pyrimidone.(VIII), and benroyl derivative (VIc) gave VII and IV.View full abstractDownload PDF (430K) -
NOBORU SHIMAHARA, KENZO SIRAKAWA, HIROSHI HIRANO1973 Volume 93 Issue 11 Pages 1484-1489
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSReaction of thiol-type thiamine sodium salt (I) with dialkylaminosulfenyl halides, sodium dialkylaminothiosulfate or sodium dialkylaminosulfenylthiosulfate gave N-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-N-[4-hydrxy-1-methyl-2-(dialkylaminodithio)-1-butenyl] formamides (II) (thiamine dialkylamino disulfides) in a good yield. Treatment of II with amines was studied and discussed. II showed full thiamine activity in growth-promoting assay using thiamine-deficient rats.View full abstractDownload PDF (698K) -
NOBORU SHIMAHARA, KENZO SIRAKAWA, HIROSHI HIRANO1973 Volume 93 Issue 11 Pages 1490-1497
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSReaction of N-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-N-[4-hydroxy-1-methyl-2-(dialkylaminodithio)-1-butenyl] formamides (I) (thiamine dialkylamino disulfides) with alkanethiols in ethanol containing 2 moles of hydrogen chloride gave N-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-N-[4-hydroxy-1-methyl-2-(alkyltrithio)-1-butenyl] formamides (II) (thiamine alkyl trisulfides) in a high yield. The mechanism of this reaction was studied and discussed. When the propyl derivative (IIa) was treated with cycteine, thiamine (IX) and S-(propyldithio) cysteine (XI) were obtained. On the other hand, treatment of 1-adamantyl derivative (IId) with cysteine gave IX, cystine, and bis (1-adamantyl) tetra-sulfide (XII). II showed full thiamine activity in growth-promoting assay using thiamine-deficient rats.View full abstractDownload PDF (757K) -
TSUGUJI NEGISHI, HIROSHI TAKAHIRA1973 Volume 93 Issue 11 Pages 1498-1508
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe incorporation of Adriamycin (14-hydroxydaunomycin), a new antibiotic possessing an antitumor activity, into Ehlrich ascites tumor cell nuclei and the interaction between Adriamycin and DNA were investigated. Intraperitoneal injection of Adriamycin[3H(G)] to mice bearing Ehlrich ascites tumor demonstrated that silver grains in its autoradiogram were localized in tumor cell nuclei. The gel filtration of tumor cell chromatin over Sephadex G-25 and of chromatin digested by trypsin over Sephadex G-200 suggested that Adriamycin was bound to DNA and not to protein of chromatin. The binding of DNA and Adriamycin in vitro was supported by some physicochemical changes such as visible absorption spectrum fluorescence intensity, polarographic behavior, and possession of non-dialytic quality in Adriamycin and thermal denaturation-renaturation behavior of DNA. RNA, apurinic deoxyribonucleic acid, apyrimidinic deoxyribonucleic acid, hyaluronic acid, chondroitinsulfate, heparin, and a high concentration of AMP and TMP seeded to be bound to Adriamycin, but the physicochemical changes were not exactly the same as those induced by DNA. The quantitative investigation of interaction between Adriamycin and DNA was made by an equilibrium dialysis procedure. It was thereby found that Adriamycin was bound to DNA according to the Langmuir-type interaction and that free energy changes of binding were 8.4 kcal/mole. Calculations showed that the saturated binding site of DNA was 1 per 5.4 bases of DNA. It was suggested that more than two kinds of binding type, perhaps including hydrogen bond and ionic bond, were present in the Adriamycin-DNA complex. Adriamycin inhibited the RNA synthesis and DNA degradation by deoxyribonuclease, depending on the DNA-Adriamycin molar ratio. The formation of DNA-Adriamycin complex can be considered to be responsible for the biological effect of Adriamycin.View full abstractDownload PDF (1413K) -
KENJI OKAMOTO, SHINICHI SHIMAMURA1973 Volume 93 Issue 11 Pages 1509-1513
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSFollowing the previous work, several new N-carbobenzoxyamino acid 4-morpholinyl esters (Arg (NO2), Asp (β-OMe), Glu (γ-OMe), Ile, Leu, Met, Thr, and Trp) were prepared. Their coupling with Gly-OEt gave the corresponding N-carboenzoxydipeptide esters. Reactions of these 4-morpholinyl esters with amino acid sodium salts in aqueous organic solvent gave the corresponding N-carbobenzoxydipeptides, while good results were not obtained in the condensations which involved sterically hindered amino acids. Young's racemization test gave a high optical purity of 98%. Further, several reactions of N-benzoylglycine 4-morpholinyl ester were examined, and it was found that the ester was comparatively stable to acetic acid or 25% HBr in acetic acid, giving about 70% recovery in both media.View full abstractDownload PDF (586K) -
SEIGO FUKUSHIMA, MASAHARU KINOSHITA, TADATAKA NORO1973 Volume 93 Issue 11 Pages 1514-1516
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSThe following compounds were synthesized : ω-(2-Methoxy-5-nitrophenyl)-2, 4-dihydroxyacetophenone (III), ω-(2-methoxy-5-nitrophenyl)-2, 4-dimethoxyacetophenone (IV), and 7-hydroxy-2'-methoxy-5'-nitroisoflavone (VI).View full abstractDownload PDF (375K) -
SHIN MATSUURA, TOSHINOBU KUNII, MUNEKAZU IINUMA1973 Volume 93 Issue 11 Pages 1517-1519
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSEupatrin, sinensetin, and 3'-hydroxy-5, 6, 7, 4'-tetramethoxyflavone were isolated from Kumis-kuching (Orthosiphon stamineus BENTH.). These compounds were identified with the respective flavones synthesized from 2-hydroxy-4, 5, 6-trimethoxyacetophenone.View full abstractDownload PDF (458K) -
Studies on Indole Derivatives. XX. Synthesis and Reactions of 3-[Cyano(methylthio)methylene]oxindoleYOSHINORI TOMINAGA, REIKO NATSUKI, GORO MATSUDA, GORO KOBAYASHI1973 Volume 93 Issue 11 Pages 1520-1522
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSApplication of sodium cyanide, to 3-bis (methylthiomethylene) oxindole (I) afforded 3-[cyano (methylthio) methylene] oxindole (II), and the reaction of II with nucleophilic reagents such as amines and active methylene compounds gave the corresponding products formed by substitution of the methylthio group of II.View full abstractDownload PDF (378K) -
YOSHINORI TOMINAGA, REIKO NATSUKI, YOSHIRO MATSUDA, GORO KOBAYASHI1973 Volume 93 Issue 11 Pages 1523-1525
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSReaction of cyclic ketenethioacetal, 3-(methylthio) thiapyrano [3, 4-b] indol-1-one (Ia, b) and active methylenes was carried out and the corresponding products (IIIa-e) with the methylthio group substituted were obtained. Reaction of 4-(methylthio)-pyrano [3, 4-b] indol-2-one with active methylenes also afforded the corresponding substituted products (IVa-c).View full abstractDownload PDF (396K) -
HIDEO NAKAO, MASAMI FUKUSHIMA, SHIN-ICHI SUGAWARA1973 Volume 93 Issue 11 Pages 1526-1529
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESS5-Cyano-2-furaldehyde and its derivatives were synthesized and their antimicrobial activities were tested. Neither series of compound possessed significant antimicrobial activity.View full abstractDownload PDF (468K) -
TAKAO INOUE, HIROKO HIRASHIMA1973 Volume 93 Issue 11 Pages 1530-1533
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSFrom the leaves of Sambucus sieboldiana BLUME, ex GRAEBN. var. Miquelii (NAKAI) HARA were isolated a colorless waxy substance which is almost composed of a mixture of α-amyrin and β-amyrin palmitates, ursolic acia, β-sitosterol, kaempferol, quercetin, sucrose, and a large amount of potassium nitrate (about 5% of dried leaves). Oleanolic acids, stigmasterol, and campesterol were detected by gas-liquid chromatography, and also glucose, fructose, and two flavonoid glycosides by paper chromatography. Chemotaxonomy of Sambucus species has been briefly discussed.View full abstractDownload PDF (563K) -
ITSUO YOSHIZAWA, MICHIYA KIMURA1973 Volume 93 Issue 11 Pages 1533-1536
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSA simple method to prepare 2-hydroxyestrone-6, 7-3H in a high yield is described. The method is based on the benzoyloxylation of estrone-6, 7-3H with benzoyl peroxide followed by acid hydrolysis as previously described.View full abstractDownload PDF (524K) -
TAKAJI KOYAMA, TAKASHI HIROTA, MASATOSHI YAMATO, SHINYA KOHKI1973 Volume 93 Issue 11 Pages 1536-1538
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSTreatment of α-formyl-(IIa) and α-acetyl-5, 6, 7, 8-tetrahydronaphthyl-2-acetonitrile (IIb) with formamide and phosphoryl chloride respectivily gave 4-amino-(IIIa) and 4-amino-6-methyl-5-(5, 6, 7, 8-tetrahydro-2-naphthyl) pyrimidine (IIIc). The same treatment of the benzoyl derivative (IIc) gave IIIa and benzamide (IV).View full abstractDownload PDF (459K) -
KIYOKAZU TAKAISHI, YUZO KAWAHARA, KATSUHIKO IKEBE1973 Volume 93 Issue 11 Pages 1538-1542
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSMaltol and sugars in the leaves of Cercidiphyllum japonicum were examined and the presence of maltol (1.8-2.3%), fructose (2.6%), glucose (3.0%), and sorbitol (1.1%) was confirmed. The high amount of sugars was correlated to the amount of maltol all the year. This correlation is interesting from biosynthetic point of view, since it has been expected that maltol is synthesized from a sugar.View full abstractDownload PDF (590K) -
MASANORI OHNISHI, HIROYOSHI OHUE, HARUO MEGURI1973 Volume 93 Issue 11 Pages 1542-1544
Published: November 25, 1973
Released on J-STAGE: May 30, 2008
JOURNAL FREE ACCESSTwo flavonoids, two toxic components, and ursolic acid were isolated from the flowers of Rhododendron linealifolium SIEB. et ZUCC. The two flavonoids were identified with azareatin and quercetin and the two toxic components were identified with grayanotoxin I and III.View full abstractDownload PDF (407K)
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