Reactions of Benzylcarbonyl Compounds with Formamide. IX. On α-Acyl-5, 6, 7, 8-tetrahydro-2-naphthylacetonitriles

Abstract

Treatment of α-formyl-(IIa) and α-acetyl-5, 6, 7, 8-tetrahydronaphthyl-2-acetonitrile (IIb) with formamide and phosphoryl chloride respectivily gave 4-amino-(IIIa) and 4-amino-6-methyl-5-(5, 6, 7, 8-tetrahydro-2-naphthyl) pyrimidine (IIIc). The same treatment of the benzoyl derivative (IIc) gave IIIa and benzamide (IV).