Total Synthesis of rac-3-(3-Oxo-17β-hydroxy-13-ethylgon-4-en-17α-yl) propionic Acid γ-Lactone

Abstract

rac-3-(3-oxo-17β-hydroxy-13-ethylgon-4-en-17α-yl)-3-propionic acid γ-lactone (VI) was prepared in 15% yield from rac-17α-ethynyl-13-ethylgona-1, 3, 5(10)-trien-17β-ol (II) through carbynylation, reduction, and hydrolysis.