^<113m>Inの混合度測定への応用(第5報)調剤における散剤と造粒製剤の混合性改善について

抄録

Some experiments were carried out on the effect of various additives powders for the improvement of mixing on some medicinal powders and granular preparations in pharmaceutical dispensing. ^113mIn was adsorbed on some medicinal powders (A) such as lactose (<74 μ), crystalline lactose (74-149 μ), corn starch, and synthetic aluminium silicate. For granular preparations (B), lactose granules with particle size of 420-590 μ and five kinds of general dispensing granules were used. Mixing ratio was 1 : 2 for A to B in principle. Effect of additive powders was determined from the coefficient of variation in radioactivity of A components using fine crystalline cellulose, dry yeast, fine lactose, and corn starch. Experimental results indicated that crystalline lactose showed a good mixing with lactose granules (420-590 μ) and other medicinal granules by the addition of 5% dried corn starch.