桔梗の薬理学的研究(第4報)粗Platycodinの実験薬理効果と桔梗の臨床治療効能との対比

抄録

The present study was undertaken to compare the pharmacological activities of crude platycodin reported previously with the clinical uses of platycodi radix in the oriental medicine. Crude platycodin shows marked antiulcerative, anti-inflammatory, hypotensive, and expectorant actions, and moderate analgesic, antipyretic, antitussive, and anticholinergic activities. Sedative, antihistaminic, and antiallergic actions were also exhibited. On the other hand, the clinical uses of platycodi radix that are inferred from 23 kinds of prescriptions used frequently in the oriental medicine are as follows. Fifty-six percent of the indications for anti-inflammation, 10.6% for expectoration, 9.7% for analgesia, 8.0% for antipyresis, 4.4% for hypotension, and 3.5% for antitussive, It was used even rarely for sedation, antiulceration, antigastritis, and antiallergy. It may be concluded that the clinical uses of platycodi radix are quite parallel with the pharmacological activities of crude platycodin, and the clinical application of the radix may be attributed approximately to the effect of crude platycodin. Furthermore, it is suggested that the radix may be also used for the control of peptic ulcer.