Abstract
In prophylactic experiments, steroidal and nonsteroidal acidic anti-inflammatory agents inhibited dose-dependently the local Shwartzman reaction, and the former also inhibited the leucocyte emigration. In therapeutic experiments, only steroidal antiinflammatory drugs were found to inhibit this reaction, when they were treated after the leucocyte accumulation. However, nonsteroidal acidic anti-inflammatory agents were found to inhibit the above reaction, when they were administered prior to leucocyte emigration. These results suggest that steroidal anti-inflammatory drugs have a membranestabilizing activity on both intact and unstable lysosomes of the emigrated leucocytes, and that nonsteroidal acidic anti-inflammatory agents have a protecting action merely on the intact lysosomes. Humoral factors such as p1asma inflammation units, erythrocyte sedimentation rate, A/G ratio, and lysocyme activity were influenced by the local Shwartzman reaction. However, it was concluded that the above inhibitory activities had no correlation with change in humoral factors.
