YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ビリミジン誘導体とその関連化合物について(第21報)5-Dimethyl-amino-6-methyl-4-oxodihydropyrimidine誘導体の合成とその鎮痛消炎作用について
千田 重男広田 耕作大谷 脩
著者情報
ジャーナル フリー

1974 年 94 巻 5 号 p. 571-576

詳細
抄録

Synthesis of 1 (or 3)-phenyl-4-oxodihydropyrimidiue (11 or 12) from the corresponding 2-thiouracil derivative (4 or 5) was investigated. These compounds (11, 12) and 3, 6-dimethyl-2-phenyl-4-oxo-3, 4-dihydropyrimidine (17) were brominated to give the 5-bromo compounds (14, 15, 19), which were allowed to react with dimethylamine. The desired 5-dimethylamino compounds (2, 3) were not obtained from 15 and 19, but 5-dimethyl-amino-6-methyl-3-phenyl-4-oxo-3, 4-dihydropyrimidine (1) was obtained from 14. Analgetic and antiinflammatory activities and acute toxicity of 1 were tested to be compared with those of 1, 3-disubstituted 5-dimethylamino-6-methyluracil (A) and aminopyrine.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top