Synthesis of Indolizine Derivatives and Their Reactions

Abstract

Indo1izine derivatives (II and V) were synthesized by the reaction of α-bismethyl-thiomethylene-2-pyridineacetonitrile (I) and dimethyl N-(2-pyridyl)-dithiocarbimidate (III) with α-haloketone compound, ethyl γ-bromocrotonate. Reaction of I with nitromethane afforded 1-cyano-2-methylthio-3--nitrosoindolizine (VIII). Dimethyl 1-carbamoyl-2-methyl thiocycl [3, 2, 2] azine-3, 4-dicarboxylate (XI) was obtained from the indolizine derivative (IX) and dimethyl acetylenedicarboxylate.